While I do not claim to have a LOT of camping experiences on both sides of the States, I have enough experience to have an opinion of what I prefer.
So, while heading west could be considered the easiest option, sometimes the thought of all of the desert landscape, makes it nice to know that on our next camping foray, we will be surrounded by trees.... many, many trees. Ahhh.... what a nice thought after camping for months on end in the barren Western landscapes that have become part of the iconic images of western and road trip movies.
The beauty of camping in the BLM lands and Refuges scattered in the west means that you have the opportunity of awaking each day to a magnificent sunrise with a beautiful palette of colors that make up the mountains. Think Zion in Utah, Valley of Fire in Nevada and don't forget Sedona in beautiful Arizona. The list of places that provide magnificent vistas and colors, depending on the time of day, is endless.
Put yourself in a very different landscape such as Florida, Tennesse or Louisiana where you cannot expect to have fantastic vistas or great photographic opportunities around every corner. What you will get is the beautiful tropical foliage that fills the eastern landscape, along with the variety of birds and four legged creatures that feed off the lush vegetation.
So, apparently, in the Americas, the world is your oyster when it comes to taking great camping road trips.